2012 Spring International Conference on Computational Biology and Bioinformatics (CBB-S 2012) will take place in Xi’an China, 26-29 May, 2012. The conference CBB-S is held under the 2012 Spring World Congress on Engineering and Technology (SCET2012). The SCET 2012 is composed of several conferences on the frontier topics in the engineering and technological subjects. The SCET 2012 conference proceedings will be published by IEEE, and the accepted papers will be indexed by Ei Compendex.