The 6^th International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2012) will be held from May 17th to 20th, 2012 in Shanghai, China. iCBBE 2012 will bring together top researchers from Asian Pacific areas, North America, Europe and around the world to exchange research results and address open issues in all aspects of bioinformatics and biomedical engineering.